Weight-Loss Drug Liraglutide Slowed Alzheimer’s Decline

B2 – Upper Intermediate

New research shows that a drug commonly used for diabetes and weight loss can reduce brain shrinkage in Alzheimer’s patients by nearly 50%.

Read the article to know more about the significant potential for repurposing existing medications to slow neurodegeneration offering hope for millions affected by Alzheimer’s globally.

https://www.imperial.ac.uk/news/articles/2025/-weight-loss-drug-liraglutide-slowed-alzheimers-decline/?

Vocabulary Questions:

  1. What does “brain shrinkage” mean? “A drug prescribed for diabetes and weight loss has been shown to reduce brain shrinkage in Alzheimer’s patients by almost 50%.” Use it in a sentence.
  2. What does “agonist” mean? “The drug, called liraglutide, is one of the glucagon-like peptide receptor (GLP-1) agonists which also includes semaglutide – known as Wegovy or Ozempic – which are licensed for managing overweight and obesity and for type 2 diabetes.” Use it in a sentence.
  3. What does “double-blind” mean? “The randomized, double-blind, placebo-controlled trial included 204 patients with mild Alzheimer’s disease seen at 24 clinics throughout the United Kingdom.” Use it in a sentence.

Discussion Questions:

  1. What surprised you most about the idea that a weight-loss drug could help slow Alzheimer’s disease?
  2. Do you think existing medicines should be tested more often for new health benefits? Why or why not?
  3. What concerns might people have about using weight-loss drugs for brain health?
  4. How could this discovery change the way doctors treat Alzheimer’s patients in the future?
  5. Would you personally feel comfortable taking a medication for a different purpose than it was originally made for? Why?
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